In looking at your Cross Frame example:
http://demo.essentialobjects.com/Demos/Menu/Features/Cross%20Frame/Frameset.htmI've noticed the EO menu does two things differently in Chrome. The first is the menu's over the center frame are not the same width, and seem to right align leaving a gap on the left. Something else not seen, but exists in our application, is if you have sub menu of those sub menus in the center frame, they won't move to the right, but appear to justify differently overlapping the submenu's.
Not sure if its a problem in Chrome or not.. yes I know its 'beta'.